| ISIS | Institute for Science and International Security | Acronym |
| ISIS | integrated standby instrument system | aerospace |
| ISIS | Intervention, Support, Independence, and Success | Community abbreviations |
| ISIS | Independent Schools Information Service | Educational abbreviations |
| ISIS | Information Services In Schools | Educational abbreviations |
| ISIS | Initiative for Schools, Industries, and Sciences | Educational abbreviations |
| ISIS | International Studies for Indiana Schools | Educational abbreviations |
| ISIS | Internet Student Information System | Educational abbreviations |
| ISIS | Iowa Student Information Services | Educational abbreviations |
| ISIS | Image Structure Information And Style | computing abbreviations and acronyms |
| ISIS | Import Support and Information System | computing abbreviations and acronyms |
| ISIS | Information Services Integration Strategy | computing abbreviations and acronyms |
| ISIS | Integrated Scientific Information System | computing abbreviations and acronyms |
| ISIS | Integrated Spatial Information System | computing abbreviations and acronyms |
| ISIS | Integrated Signals Intelligence System | Military abbreviations |
| ISIS | Integrated Systems for Installation Support | Military abbreviations |
| ISIS | Interchangeable/Substitutability Information System | Military abbreviations |
| ISIS | Image and Scanner Interface Specification | software abbreviations and acronyms |
| ISIS | Infinity Systems Integration Software | software abbreviations and acronyms |
| ISIS | Integrative Systems Implementation Software | software abbreviations and acronyms |
| ISIS | International Species Information System | software abbreviations and acronyms |
| ISIS | International Spline Interface Standard | software abbreviations and acronyms |
| ISIS | I-series Student Information System | University abbreviations |
| ISIS | Imaging Science and Information Systems department | University abbreviations |
| ISIS | Innovative Student Information Services | University abbreviations |
| ISIS | Institute for Software Integrated Systems | University abbreviations |
| ISIS | Institute of Strategic and International Studies, Kuala Lumpur, Malaysia | University abbreviations |
| ISIS | Integral Studies of Inner Sciences | University abbreviations |
| ISIS | Integrated Student Information System | University abbreviations |
| ISIS | Interactive Student Information System | University abbreviations |
