- CAIS(Community Advice and Information Service)
- CAISE(Computer Aided Integrated Software Engineering)
- CAISO(California Independent System Operator Corporation, a Regional Transmission Organization. (US))
- CAIT(Committee for Applied Instructional Technologies)
- CAJ(Canaima Airport)
- CAK(Akron-Canton Regional Airport)
- CAL(Canadian Arsenals Limited)
- CALA(Community Airborne Library Architecture)
- CALABARZON(A region in the Philippines: CAvite, LAguna, BAtangas, Rizal, queZON)
- CALAS(Consortium For African And Latin American Studies)
- CALC(Caring About Limestone Community)
- CALCE(Center for Advanced Life Cycle Engineering)
- CALCM(Conventional Air-Launched Cruise Missile)
- CALD(Cultural And Linguistic Diversity)
- CALE(Computer Aided Language Engineering)
- CALFEX(Combined Arms Live Fire Exercise)
- CALI(calliper log)
- CALICO(Computer-Assisted Language Instruction COnsortium)
- CALICS(Communication, Authentication, Location, Intentions, Condition, and Situation)
