- SPEC (Specification)
- SPECAT (SPECial CATegory)
- SPECC (Space-Enhanced Command and Control)
- SPECIAL (Strength, Perception, Endurance, Charisma, Intelligence, Agility, and Luck)
- SPEC.POP. (Special Population Students)
- SPECS (SDL Performance Evaluation of Concurrent Systems)
- SPECT (Single-photon-emission computerized tomography)
- SPECTRA (Sportsmanship, Participation, Excellence, Character, Teamwork, Respect, and Achievement)
- SPECTRE (Special Executive for Counterintelligence, Terrorism, Revenge and Extortion)
- SPECTRE — SPecial Executive for Counter (intelligence, Terrorism, Revenge and Extortion)
- SPECWAR (Special Warfare)
- SPED (Special Education)
- SPEE (Superficial punctate epithelial erosions)
- SPEED (Schoolchildren Pedestrians And Equestrians Enjoy Dropmore)
- SPEEDEX (System-wide Project for Electronic Equipment at Depots- Extended)
- SPEF (Single Program Element Funding)
- SPEG (Social Program Evaluation Group)
- SPEL (Spectralog)
- SPELL (Spelling Performance Evaluation For Language And Literacy)
- SPEM (Software Process Engineering Metamodel)
- SPETC (Solid Propellant Electro-thermal-Chemical)
- SPEW (Society for Protection of Elvish Welfare)
- SPF (Black Hills Airport (Clyde Ice Field))
- SPFM (Single Phase Flow Meter)
- SPFT (Sussex Partnership Foundation Trust)
- SPG (self-propelled gun)
