- SPEC(Specification)
- SPECAT(SPECial CATegory)
- SPECC(Space-Enhanced Command and Control)
- SPECIAL(Strength, Perception, Endurance, Charisma, Intelligence, Agility, and Luck)
- SPEC.POP.(Special Population Students)
- SPECS(SDL Performance Evaluation of Concurrent Systems)
- SPECT(Single-photon-emission computerized tomography)
- SPECTRA(Sportsmanship, Participation, Excellence, Character, Teamwork, Respect, and Achievement)
- SPECTRE(Special Executive for Counterintelligence, Terrorism, Revenge and Extortion)
- SPECTRE — SPecial Executive for Counter(intelligence, Terrorism, Revenge and Extortion)
- SPECWAR(Special Warfare)
- SPED(Special Education)
- SPEE(Superficial punctate epithelial erosions)
- SPEED(Schoolchildren Pedestrians And Equestrians Enjoy Dropmore)
- SPEEDEX(System-wide Project for Electronic Equipment at Depots- Extended)
- SPEF(Single Program Element Funding)
- SPEG(Social Program Evaluation Group)
- SPEL(Spectralog)
- SPELL(Spelling Performance Evaluation For Language And Literacy)
- SPEM(Software Process Engineering Metamodel)
- SPETC(Solid Propellant Electro-thermal-Chemical)
- SPEW(Society for Protection of Elvish Welfare)
- SPF(Black Hills Airport (Clyde Ice Field))
- SPFM(Single Phase Flow Meter)
- SPFT(Sussex Partnership Foundation Trust)
- SPG(self-propelled gun)
